4.6 Article

A unimolecular theranostic system with H2O2-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells

Journal

RSC ADVANCES
Volume 8, Issue 20, Pages 10975-10979

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ra01185k

Keywords

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Funding

  1. National Science Foundation of China [51573158, 21788102]
  2. key project of Ministry of Science and Technology of China [2013CB834704]
  3. Innovation and Technology Commission [ITC-CNERC-14SC01]
  4. Research Grants Council of Hong Kong [16301614, 16305015, 16308016, N_HKUST604/14, A-HKUST605/16]
  5. Science and Technology Plan of Shenzhen [JCYJ201602229205601482]
  6. National University of Singapore [R279-000-482-133]

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A theranostic drug delivery system composed of tetraphenyl-ethene (AIEgen), benzyl boronic ester (trigger), and doxorubicin (drug) was designed and synthesized; its utilities for cell imaging, drug delivery tracking, and cancer cell cytociding were evaluated.

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