Journal
RSC ADVANCES
Volume 8, Issue 39, Pages 21793-21797Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ra03215g
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21773017, 21503213]
- Natural Science Foundation of Jilin Province, China [20170101196JC, 20160520133JH]
Ask authors/readers for more resources
Cetuximab is a monoclonal antibody that binds to the epidermal growth factor receptor, which is important in the growth of many cancers. However, the biophysical characteristics of cetuximab as an anti-cancer drug remain elusive. In this study, we adopted atomic force microscopy to measure the mechanical properties of cancer cells following cetuximab treatment and the biomechanical properties of cetuximab and epidermal growth factor receptor interactions. Atomic force microscopy can be implemented as a platform for further investigations that target the cellular stiffness and affinity of ligand-receptor as a therapeutic choice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available