4.6 Article

Catalyst- and solvent-free approach to 2-arylated quinolines via [5+1] annulation of 2-methylquinolines with diynones

Journal

RSC ADVANCES
Volume 8, Issue 9, Pages 4584-4587

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra12716b

Keywords

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Funding

  1. National Natural Science Foundation of China [41465009, 21362002]
  2. Guangxi Natural Science Foundation of China [2017GXNSFDA198043, 2016GXNSFEA380001, 2016GXNSFGA380005, AA17204058]
  3. Ministry of Education of China [IRT_16R15]
  4. BAGUI Scholar Program of Guangxi Province of China [2016A13]

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A novel route for the synthesis of 2-arylated quinolines through a [5 + 1] annulation directly from 2-methylquinolines and diynones under catalyst-free and solvent-free conditions was disclosed. This synthetic process was atom-economic, with good tolerance of a broad range of functional groups, and with great practical worth.

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