Journal
RSC ADVANCES
Volume 8, Issue 32, Pages 17921-17926Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ra01992d
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Funding
- Department of Science and Technology, Govt. of India (SERB) [SR/FT/LS-36/2010]
- IIT Patna
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The occurrence of 7,8-dihydro-8-oxo-20deoxyguanosine (8-oxodG), thymine glycol: guanine (Tg:G) mismatch and abasic site DNA damage lesions in close proximity induce repair refractive multicomponent clustered DNA damage. Herein, the influence of abasic sites in the processing of 8-oxodG lesion and Tg: G mismatch bistranded cluster is evaluated. Abasic sites are found to impart conformational destabilization that appreciably hinders the repair activity of the other lesions whenever present in a cluster combination. The repair process reduces the formation of double strand breaks (DSBs) and renders this three-lesion combination a non-DSB forming cluster. The stability of the DNA duplex harbouring these three lesions is highly compromised due to altered base helicity and base stacking phenomena leading to impaired repair.
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