Journal
JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE
Volume 56, Issue 3, Pages 334-340Publisher
KOREAN CHEMICAL SOC
DOI: 10.5012/jkcs.2012.56.3.334
Keywords
Biphenyl-3,5-dihydro-2H-thiazolopyrimidines derivatives; Antioxidant activity; Antibacterial; Antifungal activities
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Funding
- School of Chemistry, University of KwaZulu- Natal, Westville campus, Durban, South Africa
- Department of Chemistry, Sri Venkateswara University, Tirupati, India
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A new series of ethyl 2-(4-substitutedbenzylidene)-5-(3'-(ethoxycarbonyl) biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro- 2H-thiazolo[3,2-a] pyrimidine-6-carboxylate derivatives (8a-j) were synthesized. The newly synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR, LCMS mass and C, H, N analyses. All newly synthesized compounds were screened for their In vitro antioxidant activity (Scavenging of hydrogen peroxide, Scavenging of nitric oxide radical, and Lipid peroxidation inhibitory activity), antibacterial (Escheria coli, Pseudonmonas aeruginosa (gram-negative bacteria), Bacillus subtillis, Staphylococcus aureus (gram-positive bacteria)) and antifungal (Candida albicans Aspergillus niger) studies.
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