Journal
RSC ADVANCES
Volume 8, Issue 13, Pages 6798-6804Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra13238g
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Funding
- National Natural Science Foundation of China [51503130, 51773129]
- Support Plan of Science and Technology Department of Sichuan Province, China [2017GZ0129]
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In this work, a novel and stable zwitterionic polymer (TPE-CB PUs) was prepared to realize a cellular imaging system. TPE was conjugated into the backbone of zwitterionic polyurethane, which could be well dispersed in aqueous solution and emitted strong blue fluorescence because the TPE segment was aggregated in the core of TPE-CB PUs micelles. More importantly, the TPE-CB PUs micelles showed significant stability in a large pH window and with different storage times. In addition, the micelles exhibited low cytotoxicity in HeLa cells and mainly distributed in the cytoplasm after being incubated with cells. The outstanding properties of TPE-CB PUs combining the merits of AIE and a zwitterionic segment highlight its potential for use as a cell imaging material with remarkable capability.
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