Journal
NUTRIENTS
Volume 10, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/nu10010033
Keywords
marine sponges; Poecilosclerida; Batzella; Crambe; Monanchora; guanidine alkaloids; pyrroloquinoline alkaloids; bioactivities; biomimetic synthesis
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Funding
- mission sector of the Ministry of High Education of the Arab Republic of Egypt (Egyptian Cultural Bureau in Paris, France)
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Pyrroloquinoline and guanidine-derived alkaloids present distinct groups of marine secondary metabolites with structural diversity that displayed potentialities in biological research. A considerable number of these molecular architectures had been recorded from marine sponges belonging to different marine genera, including Batzella, Crambe, Monanchora, Clathria, Ptilocaulis and New Caledonian starfishes Fromia monilis and Celerina heffernani. In this review, we aim to comprehensively cover the chemodiversity and the bioactivities landmarks centered around the chemical constituents exclusively isolated from these three marine genera including Batzella, Crambe and Monanchora over the period 1981-2017, paying a special attention to the polycyclic guanidinic compounds and their proposed biomimetic landmarks. It is concluded that these marine sponge genera represent a rich source of novel compounds with potential applications for cancer and other therapeutic areas.
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