Journal
NUCLEIC ACID THERAPEUTICS
Volume 28, Issue 5, Pages 307-311Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/nat.2018.0738
Keywords
RNase-H-dependent antisense; N-Methylcarbamoylethyl (MCE) modification; hepatotoxicity
Funding
- JSPS KAKENHI [17H04886, 26810086]
- Grants-in-Aid for Scientific Research [17H04886, 26810086] Funding Source: KAKEN
Ask authors/readers for more resources
An RNase H-dependent antisense oligonucleotide (ASO), having the 2-O-(2-N-methylcarbamoylethyl) (MCE) modification, was evaluated in vitro and in vivo. The antisense activities of an ASO having the MCE modification were comparable with those of an ASO having the 2-O-methoxyethyl (MOE) modification in both in vitro and in vivo experiments. In contrast, the hepatotoxic potential of the ASO having the MCE modification was lower than that of the ASO having the MOE modification. Thus, these findings suggested that the MCE modification could be used as an alternative to the MOE modification.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available