Journal
MATERIALS
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ma11030454
Keywords
shape fidelity; bio-printing; hybrid hydrogel
Categories
Funding
- National Science Foundation [OIA-1355466]
- National Institute of Health under COBRE: CDTSPC Grant [P20GM109024]
- Office Of The Director [1355466] Funding Source: National Science Foundation
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Three-dimensional (3D) bio-printing is a revolutionary technology to reproduce a 3D functional living tissue scaffold in-vitro through controlled layer-by-layer deposition of biomaterials along with high precision positioning of cells. Due to its bio-compatibility, natural hydrogels are commonly considered as the scaffold material. However, the mechanical integrity of a hydrogel material, especially in 3D scaffold architecture, is an issue. In this research, a novel hybrid hydrogel, that is, sodium alginate with carboxymethyl cellulose (CMC) is developed and systematic quantitative characterization tests are conducted to validate its printability, shape fidelity and cell viability. The outcome of the rheological and mechanical test, filament collapse and fusion test demonstrate the favorable shape fidelity. Three-dimensional scaffold structures are fabricated with the pancreatic cancer cell, BxPC3 and the 86% cell viability is recorded after 23 days. This hybrid hydrogel can be a potential biomaterial in 3D bioprinting process and the outlined characterization techniques open an avenue directing reproducible printability and shape fidelity.
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