Journal
ISLETS
Volume 10, Issue 4, Pages 168-174Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19382014.2018.1451281
Keywords
autoimmunity; immunosuppression; insulin independence; islet transplantation; T-cell depletion
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Funding
- Chicago Diabetes Project
- National Institute of Diabetes and Digestive and Kidney Diseases [R25DK105924]
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Islet cell transplantation is a promising functional cure for type 1 diabetes; however, maintaining long-term islet graft function and insulin independence is difficult to achieve. In this short report we present a patient with situs inversus, who at the time of islet transplantation had a 26-year history of type 1 diabetes, complicated by hypoglycemic unawareness and severe hypoglycemic events. After a single allogeneic islet transplant of a low islet mass, and despite developing de novo anti-insulin and anti-GAD65 autoantibodies, the patient has remarkably maintained insulin independence with tight glycemic control and normal metabolic profiles for 10years, after receiving prolonged non-T-cell depleting immunosuppression.
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