Journal
DRUG DESIGN DEVELOPMENT AND THERAPY
Volume 12, Issue -, Pages 967-979Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DDDT.S161904
Keywords
targets prediction; pathways analysis; action mechanism; Clematis chinensis Osbeck; Notopterygium incisum KC Ting ex HT Chang
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Funding
- Major Research Plan of Shandong Province [2016GSF202041]
- National Natural Science Foundation of China [81403080]
- Overseas Expertise Introduction Center for Discipline Innovation (111 Center) [B16046]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81421005]
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Purpose: The purpose of this study was to investigate the therapeutic mechanism(s) of Clematis chinensis Osbeck/Notopterygium incisum K.C. Ting ex H.T (CN). Methods: A network pharmacology approach integrating prediction of ingredients, target exploration, network construction, module partition and pathway analysis was used. Results: This approach successfully helped to identify 12 active ingredients of CN, interacting with 13 key targets (Akt1, STAT3, TNFsf13, TP53, EPHB2, IL-10, IL-6, TNF, MAPK8, IL-8, RELA, ROS1 and STAT4). Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis indicated that CN-regulated pathways were mainly classified into signal transduction and immune system. Conclusion: The present work may help to illustrate the mechanism(s) of action of CN, and it may provide a better understanding of antirheumatic effects.
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