Journal
CANCER DISCOVERY
Volume 8, Issue 4, Pages 386-388Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-18-0123
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Funding
- NCI grant [K12CA088084-16A1]
- MD Anderson Moonshot program
- Khalifa Bin Zayed Al Nahyan Foundation [U01CA196403, U01CA200468]
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Development of pancreatic cancer in spontaneous murine models is associated with enrichment of specific strains of gut and intratumoral bacteria that induce a tolerogenic immunosuppressive microenvironment favoring cancer progression and resistance to immunotherapies. Ablation of the microbiome with antibiotics reshapes the tumor microenvironment, inducing T-cell activation, improving immune surveillance, and increasing sensitivity to immunotherapy in established tumors. (c) 2018 AACR.
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