Journal
BIOMEDICAL OPTICS EXPRESS
Volume 9, Issue 3, Pages 1309-1322Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.9.001309
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Funding
- Stichting voor de Technische Wetenschappen (STW) [12706]
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Catheter-based radiofrequency ablation for atrial fibrillation has long-term success in 60-70% of cases. A better assessment of lesion quality, depth, and continuity could improve the procedure's outcome. We investigate here photoacoustic contrast between ablated and healthy atrial-wall tissue in vitro in wavelengths spanning from 410 nm to 1000 nm. We studied single-and multi-wavelength imaging of ablation lesions and we demonstrate that a two-wavelength technique yields precise detection of lesions, achieving a diagnostic accuracy of 97%. We compare this with a best single-wavelength (640 nm) analysis that correctly identifies 82% of lesions. We discuss the origin of relevant spectroscopic features and perspectives for translation to clinical imaging. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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