Journal
BIOMEDICAL OPTICS EXPRESS
Volume 9, Issue 3, Pages 1262-1271Publisher
Optica Publishing Group
DOI: 10.1364/BOE.9.001262
Keywords
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Funding
- Fondo de Investigaciones Sanitarias [PI09/0557]
- Redes Tematicas de Investigacion Cooperativa (RETICS-INVICTUS) [RD012/0014, PLUS RD16/0019/0010]
- Fundacio CELLEX Barcelona
- Ministerio de Economia y Competitividad/FEDER (PHOTODEMENTIA) [DPI2015-64358-C2-1-R]
- Instituto de Salud Carlos III/FEDER (MEDPHOTAGE) [DTS16/00087]
- Severo Ochoa Programme for Centres of Excellence in RD [SEV-2015-0522]
- Obra Social la Caixa Foundation (LlumMedBcn)
- Institucio CERCA
- AGAUR-Generalitat [2014SGR-1555]
- LASERLAB-EUROPE IV [EU-H2020 654148]
- Marie Curie initial training network [OILTEBIA 317526]
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In this pilot study, we have evaluated bedside diffuse optical monitoring combining diffuse correlation spectroscopy and near-infrared diffuse optical spectroscopy to assess the effect of thrombolysis with an intravenous recombinant tissue plasminogen activator (rtPA) on cerebral hemodynamics in an acute ischemic stroke. Frontal lobes of five patients with an acute middle cerebral artery occlusion were measured bilaterally during rtPA treatment. Both ipsilesional and contralesional hemispheres showed significant increases in cerebral blood flow, total hemoglobin concentration and oxy-hemoglobin concentration during the first 2.5 hours after rtPA bolus. The increases were faster and higher in the ipsilesional hemisphere. The results show that bedside optical monitoring can detect the effect of reperfusion therapy for ischemic stroke in real-time. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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