Journal
BIOINTERPHASES
Volume 13, Issue 1, Pages -Publisher
AIP Publishing
DOI: 10.1116/1.4999786
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A novel method for the generation of surface-attached hydrogel coatings and their use in biomedical applications is discussed. This short review concentrates on surface architectures that are prepared from prepolymers carrying reactive groups suitable for crosslinking via C,H insertion reactions [C,H insertion crosslinking (CHic)]. Upon photochemical or thermal activation these groups do not only induce the crosslinking of the system, but also connect the forming gel to the surface as long as the surface itself consists of an organic material. C,H groups as the reaction partner are available in abundance at practically all types of organic surfaces such as biomaterials or polymers, rendering the technique almost universally applicable. Surface-attached gels prepared this way show unique swelling properties due to the confinement of the chains, as the obtained essentially two-dimensional gels can only swell in one dimension. This anisotropic swelling does not permit penetration of the layers by macromolecules so that the surfaces become bioinert, i.e., are strongly protein and cell repellent. It is discussed how this property can be used to control the interaction of surfaces with biological species ranging from the level of biomolecules to living cells. A combination of the CHic chemistry and microstructuring techniques opens further avenues for the study of the behavior of cells to the generation of novel bioanalytical devices. (C) 2017 Author(s).
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