Journal
ACS CATALYSIS
Volume 8, Issue 7, Pages 6699-6706Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b01675
Keywords
catalysis; C8-alkylation; C-H bond activation; 1-naphthylamine; picolinamide; rhodium catalyst
Categories
Funding
- MEXT [17H06091]
Ask authors/readers for more resources
The rhodium(I)-catalyzed C-H alkylation of 1-naphthylamide derivatives with alkenes at the C8-position using a picolinamide directing group is reported. Various alkenes including styrene derivatives, alpha,beta-unsaturated carbonyl compounds, and even unactivated alkene could also be used as coupling partners. The reaction mechanism was investigated in kinetic studies, deuterium labeling studies, and control experiments. The reaction appears to proceed through a rhodium carbene intermediate, which is generated from an alkene.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available