Journal
ACS CATALYSIS
Volume 8, Issue 3, Pages 1921-1925Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.7b04060
Keywords
copper catalysis; aerobic oxidation; alkene oxyamination; amino lactone; electron-rich amines
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Funding
- University of Toledo
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A convenient alkene oxyamination compatible with a wide range of alkenoic acids and electron-rich amines is accomplished via aerobic copper catalysis. The synthetic value of this protocol is highlighted with the stereoselective formation of complex amino lactone products. In addition, product derivatizations to privileged nitrogen heterocycles have also been demonstrated via simple reduction methods. The reaction is proposed to proceed through a copper-catalyzed iodolactonization process.
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