Journal
ACS CATALYSIS
Volume 8, Issue 6, Pages 5466-5484Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b01263
Keywords
organocatalysis; aminocatalysis; enamine transformation; oxidative enamine catalysis; nucleophile
Categories
Funding
- National Natural Science Foundation of China (NSFC) [21390400, 21521002, 21672217]
- Chinese Academy of Sciences [QYZDJ-SSW-SLH023]
- National Program for Support of Top-notch Young Professionals, CAS Youth Innovation Promotion Association
- CAS one-hundred talents program (D)
Ask authors/readers for more resources
Enamine catalysis is a prevalent strategy for the fiinctionalization of aldehydes/ketones with electrophiles. Recently, the advent and development of oxidative enamine catalysis have allowed for the coupling of enamines with readily available nucleophiles under oxidative conditions, significantly expanding the domain of typical enamine catalysis. In this perspective, we summarize the recent advances in asymmetric oxidative enamine catalysis. On the basis of the oxidative strategy, these could be classified as (1) oxidation of nucleophile, (2) oxidation of enamine via single-electron transfer (SOMO catalysis), and (3) oxidation of enamine to alpha,beta-unsaturated iminium ion, i.e. oxidative iminium catalysis. These strategies have enabled efficient oxidative functionalizations of aldehydes/ketones with various O-, N-, and C-centered nucleophiles in a highly stereocontrolled manner.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available