4.8 Article

How Does Palladium-Amino Acid Cooperative Catalysis Enable Regio- and Stereoselective C(sp(3))-H Functionalization in Aldehydes and Ketones? A DFT Mechanistic Study

Journal

ACS CATALYSIS
Volume 8, Issue 8, Pages 7698-7709

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b02281

Keywords

palladium catalysis; metal-organic cooperative catalysis; C-H activation; reaction mechanism; regio- and stereoselectivities

Funding

  1. Tianjin University
  2. National Natural Science Foundation of China [21673156, 21705116]
  3. Natural Science Foundation of Tianjin City [17JCQNJC05000]
  4. University of Colorado Denver

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Density functional theory computations have elucidated the detailed mechanism and intriguing selectivities of C(sp(3))-H activation and arylation of aldehydes and ketones promoted by palladium amino acid cooperative catalysis. The amino acid cocatalyst takes up the carbonyl substrate by a condensation reaction to form an imine acid, which acts as a transient directing reagent and metathesizes with Pd(OAc)(2) (the precatalyst) to initiate active Pd(II) complexes. The reaction then proceeds through C-H bond activation, oxidative addition of Pd(II) by iodobenzene, and reductive elimination from Pd(IV) completing C-C bond formation, followed by ligand exchange to regenerate the active Pd(II) catalyst and release the arylated imine acid which continues on hydrolysis to give the final product and regenerate the amino acid cocatalyst. The C-H activation step via concerted metalation deprotonation (CMD), which is rate-and selectivity-determining, favors palladacyclic transition states with a minimum chelate ring strain and an optimal Pd(d)/C-H(a) orbital interaction. This finding reveals the origins of the regioselectivities that favor (1) the benzylic C(sp(3))-H over ortho-phenyl C(sp(2))-H activation for aromatic aldehydes and (2) the beta-primary C(sp(3))-H over gamma-primary C(sp(3))-H activation for aliphatic ketones. Incorporation of a chiral amino acid into the catalyst allows for enantioselective benzylic C(sp(3))-H arylation of aromatic aldehydes, and the enantioselectivity arises from steric and torsional strains that discriminate between the diastereomeric transition states. The computational results demonstrate rich experimental theoretical synergy and provide useful insights for the further development of C H functionalization and metal organic cooperative catalysis.

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