Journal
ACS CATALYSIS
Volume 8, Issue 7, Pages 5842-5846Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b01519
Keywords
acyl radicals; C-H activation; hydrogen atom transfer; photocatalysis; trifluoromethylthioester
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Funding
- Humboldt Foundation
- Deutsche Forschungsgemeinschaft (Leibniz Award)
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A cooperative catalysis between a photoredox and a hydrogen atom transfer (HAT) catalyst has been developed to synthesize trifluoromethylthioesters from aldehydes. This reaction is mild, highly selective, operationally simple, works under redox neutral condition, and exhibits a broad substrate scope with high functional group tolerance. The synthetic utility of this method is demonstrated by the late-stage functionalization of bioactive molecules, making it amenable for drug discovery.
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