Journal
NATURE COMMUNICATIONS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-05077-9
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Funding
- Spanish Ministry of Economy and Competitiveness [SAF2017/82886-R, SAF2015-65633-R]
- Comunidad de Madrid, CIBER Cardiovascular (Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III) [CAM S2017/BMD-3671]
- Comunidad de Madrid, CIBER Cardiovascular (Fondo Europeo de Desarrollo Regional FEDER)
- COST-Action [BM1202]
- Instituto de Salud Carlos III [MS14/00219]
- Spanish Ministry of Economy and Competitiveness (MINECO)
- Pro-CNIC Foundation
- Severo Ochoa Center of Excellence (MINECO award) [SEV-2015-0505]
- [ERC-2011-AdG 294340-GENTRIS]
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Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate antipathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats.
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