Journal
NATURE COMMUNICATIONS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-05184-7
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Funding
- National Institutes of Health (NIH) [RO1 DK093595, DP2 OD007444]
- Wellcome Trust [WT081878MA]
- European Community
- National Institute for Health Research (NIHR)
- Chronic Disease Research Foundation (CDRF)
- MRC AimHy project grant [MR/M016560/1]
- MRC [MR/N01183X/1] Funding Source: UKRI
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The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providing a uniform platform for such comparisons. Here, we present gut microbiota association analyses for 38 common diseases and 51 medications within the cohort. We describe several novel associations, highlight associations common across multiple diseases, and determine which diseases and medications have the greatest association with the gut microbiota. These results provide a reference for future studies of the gut microbiome and its role in human health.
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