4.8 Article

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Journal

NATURE COMMUNICATIONS
Volume 9, Issue -, Pages -

Publisher

NATURE PORTFOLIO
DOI: 10.1038/s41467-017-02499-9

Keywords

-

Funding

  1. Oregon National Primate Research Center (ONPRC) [P51 OD011092]
  2. NIH
  3. [R21-HD091032]
  4. [R01-HD086331]
  5. EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [K99HD090229, R21HD091032, R01HD086331, K12HD000849] Funding Source: NIH RePORTER
  6. NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA021981] Funding Source: NIH RePORTER
  7. OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [P51OD011092] Funding Source: NIH RePORTER

Ask authors/readers for more resources

Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and fetal central nervous system malformations, which are outcomes broadly referred to as the Congenital Zika Syndrome (CZS). Here we infect pregnant rhesus macaques and investigate the impact of persistent ZIKV infection on uteroplacental pathology, blood flow, and fetal growth and development. Despite seemingly normal fetal growth and persistent fetal-placenta-maternal infection, advanced non-invasive in vivo imaging studies reveal dramatic effects on placental oxygen reserve accompanied by significantly decreased oxygen permeability of the placental villi. The observation of abnormal oxygen transport within the placenta appears to be a consequence of uterine vasculitis and placental villous damage in ZIKV cases. In addition, we demonstrate a robust maternal-placental-fetal inflammatory response following ZIKV infection. This animal model reveals a potential relationship between ZIKV infection and uteroplacental pathology that appears to affect oxygen delivery to the fetus during development.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available