Journal
JOURNAL OF ORAL BIOSCIENCES
Volume 54, Issue 3, Pages 164-168Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.job.2012.07.001
Keywords
EBV; Porphyromonas gingivalis; Periodontal disease; Epigenetic regulation; Butyric acid
Categories
Funding
- Scientific Research, Japan, the Uemura Fund
- Dental Research Center
- Nihon University School of Dentistry, Tokyo
- MEXT [S1001024]
- Grants-in-Aid for Scientific Research [23592714, 24592843] Funding Source: KAKEN
Ask authors/readers for more resources
Epstein-Barr virus (EBV) is a ubiquitous human gamma herpesvirus that infects more than 90% of the world's population. EBV infection causes several human diseases, including infectious mononucleosis, autoimmune disorders, and a number of malignancies. Interestingly, evidence accumulated over the past 10 years supports the role for EBV as a pathogenic agent of periodontal disease because bacterial activities alone do not explain several of its clinical characteristics. Despite this, it remains unclear how EBV is reactivated in the oral cavity and how activated EBV leads to the progression of periodontal diseases. We focused on the microbial interaction between bacteria and viruses in the etiology of infectious disease and found that the periodontal pathogen Porphyromonas gingivalis could induce EBV reactivation via chromatin modification. Our observations provide evidence for a possible microbial interaction between bacteria and EBV that may contribute to the pathogenesis of EBV-related diseases. This review describes the molecular mechanisms involved in the maintenance of EBV latency and its reactivation by periodontopathic bacteria. In addition, we discuss possible mechanisms by which EBV reactivation may facilitate progression of periodontal disease in infected individuals. (C) 2012 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available