Journal
NATURE COMMUNICATIONS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-017-02458-4
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Funding
- Fondation pour la Recherche Medicale (FRM team)
- Ligue contre le Cancer (from the Ile de France committee)
- Association pour la Recherche sur le Cancer
- French National Research Agency [ANR-15-CE15-0009-01]
- Ligue contre le Cancer
- INSERM
- Agence Nationale de la Recherche (ANR) [ANR-15-CE15-0009] Funding Source: Agence Nationale de la Recherche (ANR)
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Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoid-resident T cell pool has not yet been done. Here we show that a substantial proportion of CD4 regulatory (Treg) and memory (Tmem) cells establish long-term residence in the SLOs of specific pathogen-free mice. Of these SLOs, only T cell residence within Peyer's patches is affected by microbiota. Resident CD4 Treg and CD4 Tmem cells from lymph nodes and non-lymphoid tissues share many phenotypic and functional characteristics. The percentage of resident T cells in SLOs increases considerably with age, with S1PR1 downregulation possibly contributing to this altered homeostasis. Our results thus show that T cell residence is not only a hallmark of non-lymphoid tissues, but can be extended to secondary lymphoid organs.
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