Journal
NATURE COMMUNICATIONS
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-04086-y
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Funding
- Wellcome Trust [081878/Z/06/Z]
- British Skin Foundation [5044i]
- Wellcome Trust
- Medical Research Council
- European Union (EU)
- National Institute for Health Research (NIHR)
- Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust
- King's College London
- NHMRC [103119]
- Erasmus MC
- Erasmus University Rotterdam
- Netherlands Organisation for Scientific Research (NWO)
- Netherlands Organisation for Health Research and Development (ZonMw)
- Research Institute for Diseases in the Elderly (RIDE)
- Netherlands Genomics Initiative (NGI)
- Ministry of Education, Culture and Science of the Netherlands
- Ministry of Health Welfare and Sport of the Netherlands
- Municipality of Rotterdam
- European Commission (DG XII)
- NIH [R01 CA49449, P01 CA87969, UM1 CA186107, UM1 CA167552]
- China National Thousand Young Talents Award
- National Natural Science Foundation of China (NSFC) [91651507]
- British Skin Foundation [5044i] Funding Source: researchfish
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The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.
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