Journal
NATURE COMMUNICATIONS
Volume 9, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-018-02942-5
Keywords
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Categories
Funding
- Lustgarten Foundation [RO1 CA154823]
- NCI, US NIH [HHSN261200800001E]
- NIH [HHSN268201100011I, R01 CA098661, UM1 CA182934, P30 CA016087, P30 ES000260]
- US NCI at the NIH [R03 CA123546-02]
- Ministry of Health of the Czech Republic [NR 9029-4/2006, NR9422-3, NR9998-3, MH CZ-DRO-MMCI 00209805]
- NCI [P50CA062924, R01CA97075]
- Sol Goldman Pancreas Cancer Research Center
- Mayo Clinic SPORE in Pancreatic Cancer [P50 CA102701]
- Geoffrey Beene Foundation [P30CA008748]
- Arnold and Arlene Goldstein Family, Foundation
- Society of MSKCC
- Kaiser Permanente [RO1CA102765]
- Group Health Cooperative
- National Health and Medical Research Council of Australia (NHMRC) [442302]
- NHMRC [1060183]
- NIH-NCI [R01CA1009767, R01CA109767-S1, R0CA059706]
- Joan Rombauer Pancreatic Cancer Fund
- California Department of Public Health
- NCI's SEER Program [HSN261201000140C]
- CDC's National Program of Cancer Registries [U58DP003862-01]
- NCI at the U.S. NIH [5R01CA098870]
- Czech Science Foundation [P301/12/1734]
- Internal Grant Agency of the Czech Ministry of Health [IGA NT 13 263]
- Baden-Wurttemberg State Ministry of Research, Science and Arts
- Heidelberger EPZ-Pancobank
- Heidelberger EPZ-Pancobank (BMBF) [01GS08114]
- BMBH (BMBF) [01EY1101]
- 5 x 1000 voluntary contribution of the Italian Government
- Italian Ministry of Health [RC1203GA57, RC1303GA53, RC1303GA54, RC1303GA50]
- Italian Association for Research on Cancer (AIRC) [12182]
- Italian Ministry of Research [FIRB - RBAP10AHJB]
- Italian FIMP-Ministry of Health [12 CUP_J33G13000210001]
- National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, UK
- American Cancer Society (ACS)
- State of Maryland
- Maryland Cigarette Restitution Fund
- National Program of Cancer Registries of the Centers for Disease Control and Prevention
- VicHealth
- Cancer Council Victoria
- Australian NHMRC [209057, 396414]
- Instituto de Salud Carlos III-FEDER, Spain
- Fondo de Investigaciones Sanitarias (FIS) [PI13/00082, PI15/01573]
- Red Tematica de Investigacion Cooperativa en Cancer, Spain [RD12/0036/0050]
- European Cooperation in Science and Technology (COST Action) [BM1204]
- Ministerio de Ciencia y Tecnologia [CICYT SAF 2000-0097]
- Fondo de Investigacion Sanitaria, Madrid, Spain [95/0017]
- Generalitat de Catalunya (CIRIT-SGR)
- Red tematica de investigacion cooperativa de centros en Cancer, Madrid [C03/10]
- Red tematica de investigacion cooperativa de centros en Epidemiologia y salud publica, Madrid [C03/09]
- CIBER de Epidemiologia (CIBERESP), Madrid
- NIH, Bethesda, MD, USA [CA-097193, CA-34944, CA-40360, HL-26490, HL-34595, CA-047988, HL-043851, HL-080467, HL-099355]
- NIH from the NCI, Bethesda, MD, USA [UM1 CA167552, UM1 CA186107, P01 CA87969, R01 CA49449]
- Hale Center for Pancreatic Cancer Research from the NCI, Bethesda, MD, USA [U01 CA21017]
- United States Department of Defense [CA130288]
- Pancreatic Cancer Action Network
- Noble Effort Fund
- Peter R. Leavitt Family Fund
- Wexler Family Fund
- Promises for Purple
- National Heart, Lung, and Blood Institute, NIH, U.S. Department of Health and Human Services [HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C]
- Common Fund of the Office of the Director of the NIH
- NCI
- NHGRI
- NHLBI
- NIDA
- NIMH
- NINDS
- National Health and Medical Research Council of Australia [1060183] Funding Source: NHMRC
- MRC [MR/N003284/1] Funding Source: UKRI
Ask authors/readers for more resources
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 x 10(-8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PAN-DoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 x 10(-14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 x 10(-10)), rs4795218 at 17q12 (HNF1B, P = 1.32 x 10(-8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 x 10(-8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
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