Journal
NATURE REVIEWS CANCER
Volume 12, Issue 8, Pages 540-552Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3319
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Funding
- Biotech Research and Innovation Centre (BRIC)
- Institute of Cancer Research (ICR)
- Cancer Research UK (CRUK)
- Breast Cancer Campaign
- Association for International Cancer Research (AICR)
- Novo Nordisk Foundation
- Worldwide Cancer Research [09-0796] Funding Source: researchfish
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The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of evidence implicating the tumour microenvironment as pivotal in all aspects of tumour initiation and progression. Members of the lysyl oxidase (LOX) family of proteins are secreted by tumours and are the subject of much effort to understand their roles in cancer. In this Review we discuss the roles of members of this family in the remodelling of the tumour microenvironment and their paradoxical roles in tumorigenesis and metastasis. We also discuss how targeting this family of proteins might lead to a new avenue of cancer therapeutics.
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