Journal
ONCOLOGY LETTERS
Volume 16, Issue 2, Pages 1924-1930Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2018.8866
Keywords
C-11-methionine positron emission tomography; glioma; MGMT promoter methylation
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Funding
- JSPS KAKENHI [JP15K15534, 16K20033]
- Grants-in-Aid for Scientific Research [16K20033] Funding Source: KAKEN
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Gliomas are genetically and histopathologically heterogeneous. Intratumoral heterogeneity in the MGMT promoter methylation status is an important clinical biomarker of glioblastoma. A higher uptake of C-11-methionine in positron-emission tomography (PET) reportedly reflects increased MGMT promoter methylation; however, non-stereotactic comparison of MGMT methylation and C-11-methionine PET images may not be accurate. The present study examined the correlation between C-11-methionine uptake and MGMT promoter methylation in non-enhancing gliomas using stereotactic image-based histological analysis. Data were collected from 9 patients with newly diagnosed non-enhancing glioma who underwent magnetic resonance imaging and C-11-methionine PET during pre-surgical examination. Clinical data were also collected from 3 patients during repeat surgery. The correlation between C-11-methionine uptake and MGMT methylation or cell density was analyzed using histological specimens obtained by multiple stereotactic sampling and an exact local comparison of C-11-methionine PET images and histological specimens was made. A total of 31 stereotactic sample sites were identified. In newly diagnosed cases, the tumor to normal uptake (T/N) ratio revealed a significant positive correlation with MGMT methylation (R=0.54, P=0.009) and a marginal correlation with cell density (R=0.42, P=0.05). In recurrent cases, the T/N ratio demonstrated no correlation with MGMT methylation (R=0.01, P=0.97) or cell density (R=0.15, P=0.70). An increased uptake of C-11-methionine in PET may reflect increased MGMT promoter methylation according to stereotactic image-based histological analysis. C-11-methionine PET could therefore be a useful tool for detecting regional MGMT promoter methylation in non-enhancing primary glioma.
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