Journal
IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION
Volume 22, Issue 3, Pages 1439-1443Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TDEI.2015.7116335
Keywords
Disposable device; microfluidics; impedance Cytometer; dielectric layer; PCB; RBCs
Funding
- Sustainable Earth Office at Nanyang Technological University
- Singapore Ministry of Education [RG 26/11]
- SUTD-MIT International Design Center [IDG11300101]
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In this paper, we report a disposable microfluidic impedance cytometer attached on a reusable printed circuit board (PCB) with dielectric layer for single cell detection. The cover slide acts as a dielectric layer which allows the AC signal to sense the impedance change cross the microfluidic channel. The microfluidic chip can be disposed; while the bottom PCB with pre-deposited electrodes is reusable after each sample test. We experimentally demonstrate that the developed device is able to selectively detect HeLa cells, a type of umor cells, and ignore Red Blood Cells (RBCs). Integration of low cost and disposable microfluidic chip with reusable PCBs widely available in the industry is of great potential in point of care diagnosis of cancer, especially in the developing countries.
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