Journal
EPIGENOMICS
Volume 10, Issue 3, Pages 321-333Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2016-0171
Keywords
cry acoustics; development; epigenetics; fetal programming; HPA axis; infant; neurobehavior; NICU network neurobehavioral scale (NNNS); placenta; trajectories
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Funding
- NIEHS NIH HHS [R01 ES022223, P01 ES022832, R01 ES029212, R01 ES025145, R24 ES028507] Funding Source: Medline
- NIH HHS [UG3 OD023347] Funding Source: Medline
- NIMH NIH HHS [R01 MH094609] Funding Source: Medline
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As the 'third brain' the placenta links the developing fetal brain and the maternal brain enabling study of epigenetic process in placental genes that affect infant neurodevelopment. We described the characteristics and findings of the 17 studies on epigenetic processes in placental genes and human infant neurobehavior. Studies showed consistent findings in the same cohort of term healthy infants across epigenetic processes (DNA methylation, genome wide, gene and miRNA expression) genomic region (single and multiple genes, imprinted genes and miRNAs) using candidate gene and genome wide approaches and across biobehavioral systems (neurobehavior, cry acoustics and neuroendocrine). Despite limitations, studies support future work on molecular processes in placental genes related to neurodevelopmental trajectories including implications for intervention.
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