Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 9, Issue 7, Pages 584-586Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.8b00276
Keywords
Fluorosulfate; sulfonyl fluoride; sulfur(VI)-fluoride; chemoproteomics; protein labeling
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Aryl fluorosulfates are finding widespread utility in chemical biology and medicinal chemistry. The context dependent engagement of tyrosine, lysine, serine, and histidine amino acid residues in functional protein sites has enabled chemogenomic and chemoproteomic techniques that demonstrate considerable promise for drug discovery and biomedical research.
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