Journal
SAUDI PHARMACEUTICAL JOURNAL
Volume 26, Issue 5, Pages 656-664Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jsps.2018.02.026
Keywords
Plumula nelumbinis; Polysaccharides; Sulfated modification; Antioxidant activity
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Funding
- National Natural Sciences Foundation of China (NNSFC) [81703384]
- Department of Science and Technology of Hunan Province of China [2014sk3014]
- Hunan Provincial Natural Science Foundation of China [2017JJ3498]
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Two novel polysaccharides, Plumula nelumbinis (P. nelumbinis) polysaccharide I (LNP I) and P. nelumbinis polysaccharide II (LNP II), were extracted and purified from P. nelumbinis, and a sulfated polysaccharide, P. nelumbinis polysaccharide III (LNP III), with a substitution degree of 0.62 was prepared from LNPI. The structures of the LNPs were preliminarily characterized using high performance size exclusion chromatography (HPSEC), gas chromatography-mass spectrometry (GC-MS), Fourier transformed infrared spectrometry (FT-IR), and nuclear magnetic resonance (NMR) spectrometry. In addition, evaluation of the antioxidant activity of the LNPs showed that they could significantly increase the proliferation of RAW264.7 macrophages (P < 0.05) and improve the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) based on cell model of H2O2-induced oxidative damage. This suggested that these LNPs may be used as potential antioxidants. (C) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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