Journal
SAUDI PHARMACEUTICAL JOURNAL
Volume 26, Issue 1, Pages 75-78Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jsps.2017.10.010
Keywords
Calotropis procera; Anti-ulcerative colitis; Anti-inflammatory; Liver function; Kidney function; Phytochemical screening
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The aim of the present study was to evaluate the anti-ulcerative colitis activity of Calotropis procera. Different extracts of the investigated plant were evaluated; total alcohol extract, polar extract and non-polar extract. All the investigated extracts at doses 200 & 400 mg/kg possessed a dose-dependent anti-ulcerative colitis potential when administrated for 5 consecutive days after colitis induction by acetic acid in rats. They reduced different parameters of UC. Only polar extract at both doses (200, 400 mg/kg) was more effective than the standard drug Prednisolone (50 mg/kg), it produced percent protection of control colitis by 63.8% and78.4% respectively, while the standard drug Prednisolone produced 54.9% protection. The anti-ulcerative colitis activity may be attributed to the active principles i.e. flavonoids. Preliminary phytochemical screening showed that the plant contains flavonoids, unsaturated sterols and/or triterpenoides, cardiac glycosides, carbohydrates or glycosides, proteins and/or amino acids, tannins and coumarins. The total alcohol extract was safe up to 4000 mg/kg and there were no side effects reported on liver and kidney functions. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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