Journal
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
Volume 11, Issue 2, Pages 109-122Publisher
SPRINGER
DOI: 10.1007/s12265-018-9793-1
Keywords
Growth; Hypertrophy; Volume overload; Pressure overload; Myocardial infarction; Computational model; Patient-specific modeling
Funding
- National Institutes of Health [U01 HL-12765]
- Hartwell Foundation
- American Heart Association
- National Institutes of Health
- National Science Foundation
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The ability to predict long-term growth and remodeling of the heart in individual patients could have important clinical implications, but the time to customize and run current models makes them impractical for routine clinical use. Therefore, we adapted a published growth relation for use in a compartmental model of the left ventricle (LV). The model was coupled to a circuit model of the circulation to simulate hemodynamic overload in dogs. We automatically tuned control and acute model parameters based on experimentally reported hemodynamic data and fit growth parameters to changes in LV dimensions from two experimental overload studies (one pressure, one volume). The fitted model successfully predicted the reported time course of LV dilation and thickening not only in independent studies of pressure and volume overload but also following myocardial infarction. Implemented in MATLAB on a desktop PC, the model required just 6 min to simulate 3 months of growth.
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