Journal
CELL DEATH & DISEASE
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41419-018-0548-3
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Funding
- Natural Science Foundation of China [81572487, 81702474, 81701329, 81472353, 81502164]
- Natural Science Foundation of Shandong Province [ZR2014HM074, ZR2017MH116, ZR2017MH015, BS2015YY004]
- Special Foundation for Taishan Scholars [ts20110814, tshw201502056, tsqn20161067]
- Department of Science and Technology of Shandong Province [2015ZDXX0801A01, 2017CXGC1502, 2015GSF118061, 2016GSF201055]
- Shandong Provincial Outstanding Medical Academic Professional Program
- Fundamental Research Funds of Shandong University [2016JC019]
- University of Bergen
- K.G. Jebsen Brain Tumor Research Centre
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Increased Actin-like 6A (ACTL6A) expression has been implicated in the development of diverse cancers and recently associated with the Hippo signaling pathway, which is known to regulate biological properties, including proliferation, tissue regeneration, stem cell biology, as well as tumorigenesis. Here we first show that ACTL6A is upregulated in human gliomas and its expression is associated with glioma patient survival. ACTL6A promotes malignant behaviors of glioma cells in vitro and in orthotopic xenograft model. In co-immunoprecipitation assays, we discover that ACTL6A physically associated with YAP/TAZ and furthermore disrupts the interaction between YAP and beta-TrCP E3 ubiquitin ligase, which promotes YAP protein degradation. Moreover, effects of ACTL6A on glioma cells proliferation, migration, and invasion could be mediated by YAP/TAZ. These data indicate that ACTL6A may contribute to cancer progression by stabilizing YAP/TAZ and therefore provide a novel therapeutic target for the treatment of human gliomas.
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