Journal
CELL DEATH & DISEASE
Volume 9, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41419-018-0647-1
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Funding
- National Natural Science Foundation of China [U1702283, 81760520, 81560471, 31300624, 81460440]
- Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University [2017FE467(-073)]
- Scientific Research Projects from Internal Research Institutions of Medical and Health Units in Yunnan PFoundation of the Yunnan Provincial Innovative Team of Bone and Soft Tissue Tumor [2015HC026]
- Foundation of the Young and Middle-aged Academic and Technical Leaders of Yunnan Province [2014HB034]
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The Hedgehog (Hh) signalling pathway is involved in cell differentiation, growth and tissue polarity. This pathway is also involved in the progression and invasion of various human cancers. Osteosarcoma, a subtype of bone cancer, is commonly seen in children and adolescents. Typically, pulmonary osteosarcoma metastases are especially difficult to control. In the present paper, we summarise recent studies on the regulation of osteosarcoma progression and metastasis by downregulating Hh signalling. We also summarise the crosstalk between the Hh pathway and other cancer-related pathways in the tumourigenesis of various cancers. We further summarise and highlight the therapeutic value of potential inhibitors of Hh signalling in the clinical therapy of human cancers.
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