Journal
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
Volume 10, Issue 7, Pages -Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a032284
Keywords
-
Categories
Funding
- European Research Council [339778]
- Wellcome Trust Senior Investigator Award
- Cancer Research UK
- City University of Hong Kong Project [9610363, 7200520]
- Croucher Foundation Project [9500030]
- Hong Kong RGC Project [CityU 21302317, N_CityU110/17]
- European Research Council (ERC) [339778] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
RNA G-quadruplex (rG4) secondary structures are proposed to play key roles in fundamental biological processes that include the modulation of transcriptional, co-transcriptional, and posttranscriptional events. Recent methodological developments that include predictive algorithms and structure-based sequencing have enabled the detection and mapping of rG4 structures on a transcriptome-wide scale at high sensitivity and resolution. The data generated by these studies provide valuable insights into the potentially diverse roles of rG4s in biology and open up a number of mechanistic hypotheses. Herein we highlight these methodologies and discuss the associated findings in relation to rG4-related biological mechanisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available