Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 43, Issue -, Pages 146-153Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2018.02.005
Keywords
Lactobacillus plantarum; Hepatoprotective; Antioxidation; Anti-inflammation; Intestinal barrier
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Funding
- Modern Agroindustrial Technology Research Systems in China [CARS-36]
- National Public Benefit Research (Agriculture) Foundation [201303085]
- Agricultural Science and Technology Innovation Program of Jilin Province [CXGC2017ZD011, C6215000219]
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Acute liver failure (ALF) is a life-threatening clinical condition resulting from massive apoptosis of hepatocytes. This study aims to examine the protective effects of Lactobacillus plantanun C88 on LPS/D-GalN-induced ALF and elucidate its underlying molecular mechanisms in mice. The results showed that L. plantarum C88 pretreatment significantly reduced the levels of plasma ALT and AST in mice with LPS/D-GalN-induced liver injury. L. plantation C88 pretreatment decreased the secretion of inflammatory cytokines. In addition, L. plantarum C88 remarkably increased the expression levels and nuclear translocations of Nrf2 mRNA in liver tissues, but inhibited NF-kappa B nuclear translocations and P65, P38 phosphorylation levels. Moreover, L. plantarum C88 enhanced the intestinal mucosa] barrier by upregulating the expressions of tight junction proteins as well as HIF-1 alpha. These results suggest that L. plantarum C88 protects against ALF associated with Nrf2 and the MAPK/NF-kappa B signaling pathways.
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