Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 41, Issue -, Pages 155-162Publisher
ELSEVIER
DOI: 10.1016/j.jff.2017.12.035
Keywords
Microbiota; Fructose; Inflammation; Wheat bran; Enterobacteriaceae
Categories
Funding
- FRS-FNRS
- EU [613979]
- European Commission
- SBO BRANDING project
- ERC [336452-ENIGMO]
- FRS-FNRS via the FRFS-WELBIO [WELBIO-CR-2012S-02R]
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We investigated the impact of the particle size of wheat bran on gut dysbiosis and inflammation induced by a fructose overload. Mice received drinking water with or without fructose (30%) and a standard diet supplemented with or without 5% of wheat bran fractions characterized by different average particle sizes (1690 pm versus 150 um) for 8 weeks. Fructose increased Enterobacteriaceae associated with higher expression of key inflammatory genes in the liver. The two wheat bran fractions differently affected specific gut bacteria known to be involved in the regulation of the gut barrier function and/or inflammatory processes. Moreover, wheat bran with small particle size was the sole fibre that reduced hepatic and systemic inflammatory markers upon high fructose intake. The anti-inflammatory effects of wheat bran may be dependent on their particle size and could be related to the changes in caecal Enterobacteriaceae.
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