Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 47, Issue -, Pages 211-219Publisher
ELSEVIER
DOI: 10.1016/j.jff.2018.05.061
Keywords
Sulfated polysaccharides; Gut microbiota; Obesity; SCFAs
Categories
Funding
- National Natural Science Foundation of China [31701601]
- Science and Technology Funds from Liaoning Education Department [2016J063]
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Sulfated polysaccharides from abalone (Haliotis discus hannai Ino) gonad (AGSP) is shown to have various bioactivities, but it remains unknown whether AGSP produces any effect on high fat diet (HFD)-induced obesity. This study indicated that AGSP inhibited weight gain and improved body composition in HFD-fed mice without reducing food consumption. Moreover, AGSP reduced fat accumulation in the liver and epididymal fat tissues of HFD-fed mice via the modulation of lipid metabolism. Such effects could be associated with the improvement of the gut microbiota as indicated by a decreased ratio of Firmicutes/Bacteroidetes and overall structure changes of the gut microbiota. Butyrate as the end product of bacterial fermentation was significantly increased in AGSP-fed mice, and thus may inhibit lipid-related gene expressions via G protein-coupled receptors-dependent pathways. In short, it suggested that AGSP can be used as beneficial polysaccharides to improve obesity and its associated disorders.
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