Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 42, Issue -, Pages 237-247Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2018.01.005
Keywords
Sesame cake extract; Chronic unpredictable stress; Antidepressant; Serotonin; Oxidative stress; Postsynaptic densities
Categories
Funding
- State Key Research and Development Plan modem food processing and food storage and transportation technology and equipment, China [2017YFD0400200]
- Young Talent Fund of University Association for Science and Technology in Shaanxi, China [20170201]
- China Postdoctoral Science Foundation [2016 M602867]
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Depression is a worldwide severe psychiatric disease associated with cognitive impairments. The aims of the present study are to investigate the preventive effects of alcoholic extract of sesame (Sesanuan indicum L.) cake (SLE) and sesamol in a chronic unpredictable mild stress (CUMS)-induced mouse model. Oral administration of SLE (600 mg/kg/day) and sesamol (10 mg/kg/day) significantly restored CUMS-induced mice antidepressant like behaviors, anhedonia, and anxiety. Importantly, supplementation of SLE and sesamol inhibited oxidative stress and improved serotonin levels in depressed mice brain. Moreover, SLE and sesamol treatment significantly prevented CUMS-induced memory loss in Y-maze and water-maze tests, which was consistent with enhanced the size of postsynaptic densities and postsynaptic density protein 95 (PSD-95) expression in mice hippocampus. These results illustrated that SLE and sesamol markedly improved CUMS-induced depression and memory loss, and provided novel insights into the mechanisms of sesamol and sesame crude extract on the regulation CUMS-induced depression and cognitive impairments.
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