Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 40, Issue -, Pages 187-196Publisher
ELSEVIER
DOI: 10.1016/j.jff.2017.11.010
Keywords
Jerusalem artichoke; Inulin; Hyperlipidemia; Enteric microorganisms
Categories
Funding
- Jiangsu Agricultural Science and Technology Independent Innovation Fund Project [CX(15)1005]
- National Key Research and Development Program of China [2016YFC0501207]
- National Science and Technology Basic Work of China [2015FY110500]
- National Key Project of Scientific and Technical Supporting Programs - Ministry of Science & Technology of Jiangsu Province [BY2015071-03, BY2016077-02, BN2016145]
- Fundamental Research Funds for the Central University [KYZ201623, YZ2016-1, KYYJ201703]
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Hyperlipidemia is currently rising at an alarming rate in human populations around the world, and new innovative ways of alleviating hyperlipidemia are needed. The effects of Jerusalem artichoke inulin on hyperlipidemia and the intestinal microflora in mice fed high-fat diet (HFD) were investigated. Inulin-treated HFD-fed hyperlipidemic mice had decreased serum lipid hepatic triglyceride (TG), hepatic total cholesterol (TC) concentrations and atherogenic index (AI). The inulin treatment increased hepatic superoxide dismutase (SOD) activity and decreased hepatic malondialdehyde (MDA) concentration. Histological analysis of liver revealed a decrease in abundance of lipid droplets in inulin-treated HFD-fed hyperlipidemic mice. Illumina high-throughput sequencing technology was used to analyze the bacterial community structure of the intestinal contents of mice. Analysis showed that the inulin treatment improved intestinal microflora; in particular, it significantly increased the number of Bifidobacterium in the intestine of HFD-fed mice. Inulin is therefore potentially potent functional food for preventing and treating hyperlipidemia.
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