Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 40, Issue -, Pages 573-581Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2017.11.045
Keywords
Proanthocyanidins; Chinese bayberry leaves; Ovarian cancer; Angiogenesis; Cell cycle; Akt
Categories
Funding
- NIH from the National Center for Research Resources [P20RR016477]
- National Institute for General Medical Sciences (NIGMS) [P20GM103434]
- NIGMS, a component of the National Institutes of Health (NIH) [P20GM104932]
- COBRE [GM102488/RR032138]
- ARIA S10 grant [RR020866]
- FORTESSA S10 grant [OD016165]
- INBRE [GM103434]
- National Natural Science Foundation of China [C200501]
- National Key Research and Development Program [2016YFD0400805]
Ask authors/readers for more resources
Ovarian cancer is the leading cause of death from gynecological malignancy and natural products have drawn great attention for cancer treatment. Chinese bayberry leaves proanthocyanidin (BLPs) with epigallocatechin-3-gallate (EGCG) as its terminal and major extension units is unusual in the plant kingdom. In the present study, BLPs showed strong growth inhibitory effects on cisplatin-resistant A2780/CP70 cells by inhibiting angiogenesis and inducing G1 cell cycle arrest. BLPs reduced the tube formation in HUVECs and attenuated the wound healing ability in A2780/CP70 cells. BLPs further reduced the level of ROS and targeted Akt/mTOR/p70S6K/4E-BP-1 pathway to reduce the expression of HIF-1 a and VEGF, and thus inhibited angiogenesis. Furthermore, BLPs induced G1 cell cycle arrest by reducing the expressions of c-Myc, cyclin Dl and CDK4, which was also in accordance with the flow cytometry analysis. Overall, these results indicated that BLPs could be a valuable resource of natural compounds for cancer treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available