Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 40, Issue -, Pages 219-228Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2017.11.011
Keywords
Panax ginseng; Ginsenoside Rg3; Antiviral activity; Gammaherpesvirus; MAP Kinases
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Funding
- National Research Foundation (NRF) - Ministry of science, ICT, and Future Planning [NRF-2015R1C1A2A01054457]
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Natural compounds from functional foods targeting viruses are considered to have important role for regulating virus-related diseases. Ginsenoside Rg3 is one of the active pharmaceutical components found in Panax ginseng C.A. Meyer which is widely used as a functional food in East Asia. In our present study, we have characterized the antiviral activities of the ginsenoside Rg3 isomers, 20(R)- and 20(S)-ginsenoside Rg3, against murine gammaherpesvirus 68 (MHV-68), a mouse model of human gammaherpesvirus which can cause various malignancies including cancer. We found that both 20(R)- and 20(S)-ginsenoside Rg3 inhibited lytic replication and viral proliferation of MHV-68, although 20(S)-ginsenoside Rg3 was more effective than 20(R)-ginsenoside Rg3. Furthermore, ginsenoside Rg3 isomers efficiently repressed chemically-induced lytic replication of human gammaherpesviruses in EBV-positive BC-3 and KSHV-positive Raji cell lines. Finally, our data showed that ginsenoside Rg3 isomers suppressed the p38 and/or the JNK-associated MAPK signaling pathways, thereby inhibiting viral replication.
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