Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 43, Issue -, Pages 196-205Publisher
ELSEVIER
DOI: 10.1016/j.jff.2018.02.007
Keywords
Grifola frondosa; Pyrrole alkaloids; Ergosterols; Anti-alpha-glucosidase; Anti-proliferative
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Funding
- High-level Leading Talent Introduction Program of GDAS [2016GDASRC-0102]
- Guangdong Province Science and Technology Project [2016A030303041, 2017A030303055]
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Previously, polysaccharides with hypoglycemic effects from G. frondosa were reported by us. To explore compounds against alpha-glucosidase and human tumor cells, three extractive fractions (GF-1-GF-3) were prepared from G. frondosa ethanol extraction (GF) by chromatographic column. Rather than GF-1 and GF-2, the fraction GF-3 demonstrated inhibitory actions against alpha-glucosidase and proliferation of human tumor cells dominantly. To identify the bioactive compounds in GF-3, one new compound named pyrrolefronine together with 19 known ones, which included seven pyrrole alkaloids, nine ergosterols and three others, were isolated and characterized from GF-3. Significantly, pyrrole alkaloids were found in G. frondosa for the first time, showing potent inhibition against alpha-glucosidase. Obtained ergosterols displayed inhibition against proliferation of tumor cells. This study provides a basis for further development and utilization of G. frondosa as natural nutraceuticals and functional food ingredients.
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