Journal
ONCOTARGETS AND THERAPY
Volume 11, Issue -, Pages 3003-3011Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S158206
Keywords
HIF-1 alpha; chemo-/radioresistance; cancer
Categories
Funding
- National Natural Science Foundation of China [81760472, 81702580]
- Natural Science Foundation of Jiangxi Province [20171BAB205066]
- Innovative Special Funds for graduate students of Gannan Medical University [YC2016-X004]
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Chemo-/radioresistance is a major obstacle in clinical oncology. The precise failure mechanisms of chemo-/radioresistance are multifactorial failures. It is now widely accepted that a tumor hypoxia microenvironment contributes significantly to chemo-/radioresistance. Hypoxia is the most common and obvious neoplastic microenvironment and is due to the rapid proliferation of tumor cells. HIF-1 alpha is a principal molecular mediator of adaptability to hypoxia in tumor cells. HIF-1 alpha activation leads to the transcription of a plethora of target genes that promote physiological changes associated with chemo-/radioresistance, including increasing the ability of DNA repair, the inhibition of apoptosis, and alterations of the cellular metabolism. Moreover, recent findings suggest that HIF-1 alpha-activated autophagy is a crucial factor in the promotion of cell survival under the distressed microenvironment, thereby leading to the chemo-/radioresistance. This chapter presents an overview of the role of HIF-1 alpha in chemo-/radioresistance of tumor cells.
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