Journal
ONCOTARGETS AND THERAPY
Volume 11, Issue -, Pages 2185-2193Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S157058
Keywords
breast cancer; Hippo signal pathway; metastasis
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Funding
- National Natural Science Foundation of China [81473687]
- Shandong Provincial Natural Science Foundation, China [ZR2009CM039, ZR2013HM038]
- Health Science and Technology Plan of Shandong Health Science Association [2016BJ0015]
- Tai'an Science and Technology Plan [2015NS2082]
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The Hippo pathway is a novel and highly conserved mammalian signaling pathway. Mutations and altered expression of core Hippo pathway components promote the migration, invasion, malignancy, and chemotherapy resistance of breast cancer cells. In cancer metastasis, tumor cells must detach from the primary tumor, invade surrounding tissue, and enter and survive in a foreign microenvironment. The metastatic potential of breast cancer is closely related to individual patient genetic profile. Nevertheless, the exact molecular mechanism that regulates the Hippo pathway in breast cancer metastasis is yet to be fully elucidated. This article discusses the function and regulation of the Hippo pathway, with focus given to its role in the context of breast cancer metastasis.
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