Journal
MEDCHEMCOMM
Volume 9, Issue 2, Pages 254-263Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7md00477j
Keywords
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Funding
- Science and Technology Project of Guangdong Province [2013B090700015]
- Scientific Research Projects of State Administration of TCM [JDZX2015205]
- Traditional Chinese Scientific and Technological Research Projects of Guangdong Provincial Hospital [YN2013B1N02, YN2014ZH02]
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Ilex latifolia Thunb is a kind of herbal tea and widely consumed as a functional tea beverage in Asian countries. In this study, polyphenols were extracted from I. latifolia and the major compounds were identified by liquid chromatography-mass spectrometry (LC-MS), then the effect on oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation was investigated. Results showed that the polyphenols could significantly inhibit ox-LDL-induced macrophage foam cell formation and suppress lipid droplet accumulation and cholesterol uptake in RAW 264.7 cells. Additionally, the secretion of pro-inflammatory cytokines, such as tumor necrosis factor (TNF-), interleukin (IL)-1, IL-6 and inducible nitric oxide synthase (iNOS), was significantly inhibited. Moreover, the polyphenols could suppress the expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and clusters of differentiation 36 (CD 36), which were receptors for ox-LDL. Mechanistically, I. latifolia polyphenols could inhibit macrophage foam cell formation by suppressing NF-B activation and phosphorylation of ERK1/2.
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