Journal
MEDCHEMCOMM
Volume 9, Issue 1, Pages 12-21Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7md00528h
Keywords
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Funding
- National Institutes of Health [GM055769, AI106733, AI10721]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI106733, R01AI106721] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM055769] Funding Source: NIH RePORTER
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While broad spectrum antibiotics play an invaluable role in the treatment of bacterial infections, there are some drawbacks to their use, namely selection for and spread of resistance across multiple bacterial species, and the detrimental effect they can have upon the host microbiome. If the causative agent of the infection is known, the use of narrow-spectrum antibacterial agents has the potential to mitigate some of these issues. This review outlines the advantages and challenges of narrow-spectrum antibacterial agents, discusses the progress that has been made toward developing diagnostics to enable their use, and describes some of the narrow-spectrum antibacterial agents currently being investigated against some of the most clinically important bacteria including Clostridium difficile, Mycobacterium tuberculosis and several ESKAPE pathogens.
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